NIH Clinical Center
Dept. of Lab Medicine | Dept. of Transfusion Medicine | Anatomic Pathology Test Guide
  
 
Test Name:Standard Renal Clearance
Protocol Use Only:
Department:Laboratory Medicine
Lab Area:Mayo Medical Labs
Last Modified on:02/01/2011 06:12:57 PM
Synonyms:inulin clearance, iothalamate, filtration fraction
 
Reference Ranges:

Standard Renal Clearance
Performed at Mayo Medical Labs, Rochester MN
Effective 07Dec10 – present:
GFR (glomerular filtration rate) 20 years: 87-141 mL/min/SA
Iothalmate decreases by 4.95 mL/min/decade
Iothalamate Clearance  mL/min/SA  
<=19Y:  Not established
20Y: 87-141
21Y: 86-140
22Y: 86-140
23Y: 85-139
24Y: 85-139
25Y: 84-138
26Y: 84-138
27Y: 83-137
28Y: 83-137
29Y: 82-136
30Y: 81-136
31Y: 81-136
32Y: 81-135
33Y: 80-135
34Y: 80-134
35Y: 79-134
36Y: 79-133
37Y: 78-133
38Y: 78-132
39Y: 77-132
40Y: 77-131
41Y: 76-131
42Y: 76-130
43Y: 75-130
44Y: 75-129
Para-aminohippurate (PAH) Clearance  mL/min/SA 
0-19Y:Not established
20Y-29Y: >448
30Y-39Y: >413
40Y-49Y: >378
50Y-59Y: >343
60Y-69Y: >308
70Y-79Y: >273
80Y-89Y: >239
90Y-99Y: >203
Filtration Fraction  %  
>=16Y: 18 – 22

Effective 06Sep02 – 06Dec10:
Reference Values:  GFR (glomerular filtration rate) and RPF (renal plasma flow ) are age dependent.  Normal values for GFR (iothalamate or inulin) are > 90 mL/min per 1.73 m2  for 20-year-old persons, decreasing by 4 mL/decade.  Normal values for RPF (para-aminohippuric acid -PAH) are > 448 mL/min per 1.73 m2 (previously 400 mL/min per 1.73 m2) for 20-year-old persons, decreasing by 35 mL/decade.

Inulin Clearance (Exogenous)  mL/min*   (SI: mL/s = 0.00963 x mL/min)
20Y-29Y   >90
30Y-39Y   >86
40Y-49Y   >82
50Y-59Y   >78
60Y-69Y   >74
70Y-79Y   >70
80Y-89Y   >66
90Y-99Y   >62
100Y-109Y >58
109Y-119Y >54

PAH Clearance, corrected  mL/min*   (SI: mL/s = 0.00963 x mL/min)
20Y-29Y   >448
30Y-39Y   >413
40Y-49Y   >378
50Y-59Y   >343
60Y-69Y   >308
70Y-79Y   >273
80Y-89Y   >239
90Y-99Y   >203
100Y-109Y >168
110-119Y   >133

Filtration Factor  percent   (SI: fraction = 0.01x percent)
18 – 22

Effective 08Mar95 – 05Sep02:
Inulin Clearance (Exogenous)  mL/min*   (SI: mL/s = 0.00963 x mL/min)
20Y-29Y   90 – 130
30Y-39Y   86 – 126
40Y-49Y   82 – 122
50Y-59Y   78 – 118
60Y-69Y   74 – 114
PAH Clearance, corrected  mL/min*   (SI: mL/s = 0.00963 x mL/min)
20Y-29Y   400 – 700
30Y-39Y   383 – 683
40Y-49Y   366 – 666
50Y-59Y   349 – 649
60Y-69Y   332 – 632
Filtration Factor  percent   (SI: fraction = 0.01x percent)
18 – 22

* Corrected to 1.73 m2  body surface area

 
 
 

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